All Chillicothe fire stations were called to the Wednesday blaze.
Chillicothe firefighters responded to a house fire, Wednesday. Interim Fire Chief Jeff Creed said his department was dispatched to the two-story home, 342 Shannon Drive, at 1:43 p.m.
While the house did not suffer a total loss, Creed said the home is uninhabitable.
The residents were not home when the fire started.
Investigators are still trying to determine what caused the blaze.