The names of those involved have not yet been released.
The Highway Patrol is investigating a single vehicle crash that occurred on U.S. 23 North near George Hollow Road shortly after 10:30 Friday morning.
According to the Patrol, a northbound vehicle veered off the right side of the road, crashed into an embankment, and rolled over.
A female driver was flown by helicopter to Wexner Medical Center in Columbus while a male passenger in the vehicle was taken to Adena Medical Center. The male passenger was later transported to a hospital in Columbus.
The identity of the two crash victims are yet to be released.