Western Avenue was closed between Gerber Avenue and Water Street while police investigate crash.
A head on injury crash occurred Sunday morning on Western and Gerber avenues in Chillicothe.
A Ford Freestar was traveling westbound and a Dodge Caravan was traveling eastbound when they collided.
The Dodge was pushed up onto the curb in the crash and both vehicles sustained significant damage.
At least three people were injured, one of whom has been flown by medical helicopter to a Columbus hospital said Police Chief Roger Moore.
One of the drivers, is said to be six months pregnant.
More Details were not immediately available.